Fleming Initiative Research Associate in High-Throughput Medicinal Chemistry

Following a to support the efforts to combat antimicrobial resistance (AMR), we are seeking a talented Research Associate to join the team in the group of at Imperial College London. This role will use medicinal chemistry and high-throughput direct-to-biology (D2B) approaches to rapidly synthesise large chemical libraries that will support the generation of high-throughput mass spectrometry (MS) data to power state-of-the-art Artificial Intelligence (AI) and Machine Learning (ML) models to build a chemical ‘rule book’ for small molecule accumulation in bacteria. The position is available full time, starting in June 2026 (or as soon as possible thereafter).

Antimicrobial resistance (AMR) represents a significant and growing global health threat, with recent projections estimating that 39 million deaths will be directly attributed to AMR between 2025–2050. Of particular concern are Gram-negative bacteria which possess two cell membranes, including a hard-to-penetrate outer membr...