In Silico Biophysical Characterization of PFAS Toxicokinetics: From Passive Membrane Permeation to Active Transport Modulation at Renal and Placental Barriers
Inserm U1248 Pharmacology & TransplantationJob Description
Topic description
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants whose toxicokinetics (TK) and mechanisms of action remain poorly understood, particularly regarding their passage through critical biological barriers. This PhD project aims to decipher the molecular mechanisms governing the interactions of PFAS with the placental and renal barriers at the atomic scale. The objective is to overcome the limitations of current models by simulating the precise physicochemical events underlying both passive permeation and active transport.
The project will rely on advanced computational chemistry and molecular dynamics (MD) techniques, structured around three key axes:
Apply for this Job
Submit your application for the In Silico Biophysical Characterization of PFAS Toxicokinetics: From Passive Membrane Permeation to Active Transport Modulation at Renal and Placental Barriers position at Inserm U1248 Pharmacology & Transplantation.
Apply Now Save for Later