PhD candidate in Spatial Systems Biology for Translational Oncology

Description
We are seeking a motivated new PhD candidate who wants to join an exciting collaborative research program within the VIB-Center for Inflammation Research between the Guilliams, Saelens and Saeys teams.
In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit several types of spatial growth patterns which correlate with therapy efficiencies and overall survival (Vermeulen et al. J Pathol. 2001 , Nielsen et al. Mod Pathol. 2014 , Baldin et al. J Pathol Clinical Research 2021 , Frentzas et al. Nature Medicine 2016 ). What is exactly driving these growth patterns is unknown, although the involvement of the tumor microenvironment is clear. These patterns can be mimicked with in vivo models of metastasis, which provides unique opportunities to mechanistically dissect what drives the different cell states. You will link clinically relevant phenotyp...