Research Technician – IgA Antibody Production and Development

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About PHARMIgA

Most therapeutic antibodies currently used to treat disease are based on a single antibody class: IgG. While highly effective in the bloodstream, IgG antibodies are often less effective at mucosal surfaces such as the lungs and gastrointestinal tract. These tissues are central to major unmet medical needs, including respiratory infections, inflammatory diseases, and several forms of cancer.

In contrast, IgA antibodies are naturally abundant at mucosal surfaces, where they play a key role in immune defense. IgA can efficiently neutralize pathogens and engage immune cells through mechanisms distinct from IgG. Despite their therapeutic potential, very few IgA-based therapeutics have reached the clinic. Development remains technically challenging due to complex production processes, limited scalable manufacturing methods, and the lack of standardized models and infrastructure.

PHARMIgA was established to address ...