Senior Scientist II/Associate Principal Scientist, Pharmacology

SUMMARY OF THE ROLE 

You will lead in vivo pharmacology and immune monitoring to enable data-driven progression of programs from discovery toward translation, with priority focus on (1) cell therapy (CAR-T), followed by (2) immuno-oncology and (3) immunology. You will own key humanized mouse platforms and associated ex vivo and in vivo CAR-T characterization workflows, delivering rigorous, decision-enabling datasets that inform candidate selection, dose/regimen strategy, mechanism-of-action understanding, and translational biomarker hypotheses. 

ROLES & RESPONSIBILITIES 

Humanized mouse CAR-T in vivo strategy (core priority): Design and deliver in vivo studies in humanized mouse systems to evaluate CAR-T anti-tumor activity, expansion/engraftment, persistence, trafficking, and pharmacodynamics. Translate program hypotheses into clear endpoints, sampling schedules, and pre-defined decision criteria to support candidate ranking, construct optimization, ...