Senior Scientist-LVV, Process Development

AstraZeneca

Full time China, Shang Hai Shi Life Scientists

Posted:

March 01, 2026

Location:

China, Shang Hai Shi, China

Job Description

Major responsibilities 
Plan dual-path development strategies for adherent (cell factories/fixed-bed) and suspension (HEK293-based) processes and assess platformization and scale-up pathways.
Define the relationships between critical quality attributes (CQAs) and critical process parameters (CPPs) to establish the upstream control strategy and design space (proven acceptable ranges, PAR), supporting late-stage regulatory filings.
Optimize upstream processes (, DNA:PEI ratio, plasmid quantity, cell density, temperature/DO/pH, feeding and medium exchanges, harvest window) and implement robustness-by-design to mitigate inter-batch variability.
Develop scale-up strategies, execute engineering runs, and support late-clinical/PPQ readiness.
Transfer the process to internal GMP manufacturing or CDMOs, author process development reports, batch records, SOPs, and risk assessments (FMEA).
Lead or contribute to quality activities during manufactur...
                

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Job Overview

Job Type: Full time

Location: China, China

Posted: March 01, 2026

Deadline: April 10, 2026